Here is a fork of the tippecanoe tool originally developed by Mapbox that allows building vector tilesets of large collections of features in different formats, including FlatGeobuf.

tippecanoe: Build Big Vector Tilesets of Thematic Data

This blog post demonstrates visualizing a 12.5 GB GML file in QGIS by converting the data to FlatGeobuf format and consuming it directly from a cloud server.

Using Large Datasets Converted to FlatGeobuf in QGIS

Check out this interactive notebook demonstrating using spatial queries on a 4GB FlatGeobuf dataset hosted on Microsoft Azure blob storage and visualizing it in Leaflet.

Archive: Flatgeobuf

tippecanoe: Build Big Vector Tilesets of Thematic Data

Using Large Datasets Converted to FlatGeobuf in QGIS

Spatial Queries With FlatGeobuf